ea0016oc6.4 | Metabolism and cardiovascular | ECE2008
Wellhoner Peter
, Horster Ruth
, Jacobs Friederike
, Sayk Friedhelm
, Heutling Dennis
, Lehnert Hendrik
, Dodt Christoph
The melanocortin system plays a significant role in the hypothalamic regulation of body weight and energy expenditure. Prolonged central administration of the melanocortin receptor 4 (MC-4) agonist ACTH(4-10) reduces body weight in animals and humans by increasing energy expenditure and by reducing food intake. The aim of this study was to investigate the effect of intranasally administered alpha-MSH on local lipolysis in subcutaneous adipose tissue and on sympathetic nerve ac...